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Relationship between mycotoxin contamination in feed and necrotic enteritis

Mycotoxin contamination predisposes for the development of necrotic enteritis

Necrotic enteritis, a bacterial infection caused by Clostridium perfringens, is one of the most common poultry diseases worldwide.

The acute form of the disease leads to increased mortality (up to 1% per day) together with the general and digestive signs that we described in this article.

In the subclinical form, the damage to the intestinal mucosa caused by C. perfringens leads to a worsening of the growth rate and the feed conversion ratio. The occurrence of the subclinical form has increased in countries where the use of antibiotic growth promoters has been reduced or banned.

Clostridium perfringens is a bacterium that is naturally present in the environment of the farm, in feed and in the gastrointestinal tract of healthy animals and humans. The disease starts when there is an abnormal overgrowth, especially in the small intestine. An intestinal environment with a high concentration of proteins, as well as low immunity and gut flora imbalance, promote the overgrowth of Clostridium perfringens.

Mycotoxin contamination predisposes for the development of necrotic enteritis

It has been demonstrated that mycotoxin contamination in feed predisposes for the development necrotic enteritis.

There are four possible mechanisms of action for mycotoxin toxicity in necrotic enteritis:

1. Mycotoxins have a negative impact on the morphology of the intestinal epithelium

Deoxynivalenol and fumonisins have been reported to reduce the length of the small intestine, the height of the villi and the depth of the crypts. Such changes reduce the surface available to absorb nutrients, which ultimately results in an increase of non-absorbed feed proteins in the lumen of the intestine,  promoting the growth of Clostridium.

Mycotoxin contamination predisposes for the development of necrotic enteritis

2. Mycotoxins alter the epithelial barrier function

Deoxynivalenol, fumonisins and ochratoxin A have a toxic effect on the intestinal epithelial cells and on tight junctions, disrupting the intestinal barrier (learn more about the importance of gut barrier here). The epithelium becomes more permeable and proteins from the plasma leak into the lumen of the intestine, promoting the growth of Clostridium.

Mycotoxin contamination predisposes for the development of necrotic enteritis

3. Mycotoxins depress local digestive immune system

In poultry, more than 70% of the immune defenses are located in the digestive system, spread through the GALT (gut-associated lymphoid tissue), Peyer’s patches, mesenteric lymph nodes, and cecal tonsils.

Whenever there is a disfunction of the local digestive immunity, it is easier for pathogenic bacteria such as Clostridium perfringens to proliferate.

There are four main groups of mycotoxins that impair the digestive immune system:

  • Aflatoxins and ochratoxins decrease the production of antibodies (immunoglobulins A and M)
  • Fumonisins and trichothecenes reduce the production of interleukins and interferon (small proteins that regulate the immune responses).

Mycotoxin contamination predisposes for the development of necrotic enteritis

4. Mycotoxins affect the composition of digestive microbiota

The effect of mycotoxins on intestinal microbiota is not clearly understood yet, but, as mycotoxins have antibacterial activity, presumably they cause imbalances in intestinal microbial populations that may potentially lead to an overgrowth of pathogens such as Clostridium perfringens.

Recent research has shown that, in poultry:

  • The continued ingestion of fumonisins during two weeks reduces the diversity of the ileal microbiota.
  • Exposure to fumonisins, aflatoxins and ochratoxins diminishes the count of Lactobacillus species

Mycotoxin contamination predisposes for the development of necrotic enteritis

In conclusion

Whenever there is an outbreak of necrotic enteritis or the suspicion of a subclinical infection by Clostridium perfringens, it is necessary to investigate the mycotoxin contamination of the feed as one of the possible causes.

Products of choice

PlusBind© is the mycotoxin binder of choice to prevent the negative effects of mycotoxins on gut health.

On the other hand, products based on plant extracts with microbiocide and prebiotic properties, such as GrowthPlus© and PlusProtect Digestive©, help to restore or maintain gut heath, preventing the overgrowth of Clostridium perfringens.

For more information on this topic and on our products, do not hesitate to contact us through info@plusvet.eu

Picture of Clostridium found here.  Icons found here.
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Posted in: GrowthPlus, GrowthPlus Poultry, Gut health, Mycotoxin binders, Poultry

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